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Article

Characterization of Exome Variants and Their Metabolic Impact in 6,716 American Indians from the Southwest US.

American journal of human genetics - 6 Aug 2020

Kim Hye In, Ye Bin, Gosalia Nehal, Köroğlu Çiğdem, Hanson Robert L, Hsueh Wen-Chi, Knowler William C, Baier Leslie J, Bogardus Clifton, Shuldiner Alan R, Van Hout Cristopher V

Abstract excerpt

Applying exome sequencing to populations with unique genetic architecture has the potential to reveal novel genes and variants associated with traits and diseases. We sequenced and analyzed the exomes of 6,716 individuals from a Southwestern American Indian (SWAI) population with well-characterized metabolic traits. We found that the SWAI population has distinct allelic architecture compared to populations of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32640185
DOI: 10.1016/j.ajhg.2020.06.009
PMCID: PMC7413855

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