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Article

Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities).

Arteriosclerosis, thrombosis, and vascular biology - 1 Mar 2017

Pankow James S, Tang Weihong, Pankratz Nathan, Guan Weihua, Weng Lu-Chen, Cushman Mary, Boerwinkle Eric, Folsom Aaron R

Abstract excerpt

OBJECTIVE: Previous studies have identified common genetic variants in 4 chromosomal regions that together account for 14% to 15% of the variance in circulating levels of protein C. To further characterize the genetic architecture of protein C, we obtained denser coverage at some loci, extended investigation of protein C to low-frequency and rare variants, and searched for new associations in genes known to...

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Topics

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Share to Adaptor Proteins, Vesicular Transport
Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cadherins

Share to Cholesterol, LDL

Share to Chromosomes, Human, Pair 1

Share to Hemostasis

Share to Protein C

Share to Triglycerides

Source

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Identifiers

PMID: 28082259
DOI: 10.1161/ATVBAHA.116.308109
PMCID: PMC5376064

Genes

CELSR2
EDEM2
PROC
PROCR
PSRC1
SORT1
GCKR

Provenance

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