Article
Effect of the SORT1 low-density lipoprotein cholesterol locus is sex-specific in a fit, Canadian young-adult population.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme - 1 Feb 2013
Karlos Angela, Shearer Jane, Gnatiuk Elizabeth, Onyewu Chiatogu, Many Gina, Hoffman Eric P, Hittel Dustin S
Abstract excerpt
The SORT1 locus was originally identified by genome-wide association studies of low-density lipoprotein cholesterol (LDL-C) in adults. Although the effect sizes of this locus are relatively small, we hypothesized that a younger population would show a greater genetic effect because of fewer confounding variables. As such, we investigated the association between the SORT1 locus and LDL-C in a group of healthy...
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