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Article

Identification and characterization of colorectal-cancer-associated SNPs on the SMAD7 locus.

Journal of cancer research and clinical oncology - 1 Dec 2023

Liu Zhao, Zhao Yihan, Song Hongli, Miao Huaxue, Wang Yingying, Tu Chuntian, Fu Tianyun, Qin Juliang, Du Bing, Qian Min, Ren Hua

Abstract excerpt

PURPOSE: Genome-wide association studies have identified SMAD7 as a colorectal cancer (CRC) susceptibility gene. However, its underlying mechanism has not yet been characterized. This study screened functional SNPs (fSNPs) related to colorectal cancer through Reel-seq and obtained regulatory proteins on functional SNPs. METHODS: The candidate fSNPs on the SMAD7 locus were screened by Reel-seq method. Eight SNPs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37721570
DOI: 10.1007/s00432-023-05402-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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