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Article

RPS20 as a colorectal cancer predisposition gene: an integrated review of the literature and evaluation in 9738 cases and 161,403 controls.

Familial cancer - 11 Jun 2026

Amanullah Anusha, Fernández-Tajes Juan, Gul Guler, Thorn Steve, Soriano Ignacio, Ward Joseph C, Sherwood Kitty, Tomlinson Ian

Abstract excerpt

Germline variants in Ribosomal Protein S20 (RPS20) have been reported to predispose to colorectal cancer (CRC) based on occurrence in a total of 3455 CRC cases and co-segregation with disease in 3 families. RPS20 encodes a component of the ribosomal 40 S subunit, but the mechanism by which the variants might influence CRC risk remains unclear. The current study assessed the association of RPS20 variants with CRC...

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Identifiers

PMID: 42274899
DOI: 10.1007/s10689-026-00582-z

Genes

RPS20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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