Article
FGFR Alterations in Thyroid Carcinoma: A Novel Class of Primary Drivers with Significant Therapeutic Implications and Secondary Molecular Events Potentially Mediating Resistance in Thyroid Malignancy.
Thyroid : official journal of the American Thyroid Association - 1 Sept 2024
Sabbagh Mark F, Janovitz Tyler, Dias-Santagata Dora, Siegmund Stephanie, Nardi Valentina, Wirth Lori J, Randolph Gregory W, Lennerz Jochen K, Decker Brennan, Nose Vania, Alzumaili Bayan A, Faquin William C, Barletta Justine A, Le Long P, Iafrate A John, Sadow Peter M, Fisch Adam S
Abstract excerpt
Background: Diagnostic classification of thyroid malignancy is primarily accomplished through examination of histomorphological features and may be substantiated and clarified by molecular data. Individual molecular drivers show relatively robust and specific associations with histological subtypes of thyroid malignancy, including BRAF sequence variants and kinase gene fusions in papillary thyroid carcinoma,...
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