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Article

Modelling Role of Protective and Nonprotective HLA Allele Inducing Different HIV Infection Outcomes.

Bulletin of mathematical biology - 13 Jul 2024

Xu Shilian

Abstract excerpt

Human immunodeficiency virus (HIV) infects CD4+ cells and causes progressive immune function failure, and CD8+ cells lyse infected CD4+ cell via recognising peptide presented by human leukocyte antigens (HLA). Variations in HLA allele lead to observed different HIV infection outcomes. Within-host HIV dynamics involves virus replication within infected cells and lysing of infected cells by CD8+ cells, but how...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39003370
DOI: 10.1007/s11538-024-01334-9
PMCID: PMC11246342

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