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Article

Saturated lysing efficiency of CD8+ cells induced monostable, bistable and oscillatory HIV kinetics.

Mathematical biosciences and engineering : MBE - 22 Oct 2024

Xu Shilian

Abstract excerpt

Effector CD8+ cells lyse human immunodeficiency viruses (HIV)-infected CD4+ cells by recognizing a viral peptide presented by human leukocyte antigens (HLA) on the CD4+ cell surface, which plays an irreplaceable role in within-host HIV clearance. Using a semi-saturated lysing efficiency of a CD8+ cell, we discuss a model that captures HIV dynamics with different magnitudes of lysing rate induced by different HLA...

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Identifiers

PMID: 39696867
DOI: 10.3934/mbe.2024324

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