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Article

Unveiling New Genetic Variants Associated with Age at Onset in Alzheimer's Disease and Frontotemporal Lobar Degeneration Due to C9orf72 Repeat Expansions.

International journal of molecular sciences - 7 Jul 2024

Longobardi Antonio, Bellini Sonia, Nicsanu Roland, Pilotto Andrea, Geviti Andrea, Facconi Alessandro, Tolassi Chiara, Libri Ilenia, Saraceno Claudia, Fostinelli Silvia, Borroni Barbara, Padovani Alessandro, Binetti Giuliano, Ghidoni Roberta

Abstract excerpt

Alzheimer's disease (AD) and Frontotemporal lobar degeneration (FTLD) represent the most common forms of neurodegenerative dementias with a highly phenotypic variability. Herein, we investigated the role of genetic variants related to the immune system and inflammation as genetic modulators in AD and related dementias. In patients with sporadic AD/FTLD (n = 300) and GRN/C9orf72 mutation carriers (n = 80), we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39000564
DOI: 10.3390/ijms25137457
PMCID: PMC11242823

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