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Article

HIV-1 capsid uncoating initiates after the first strand transfer of reverse transcription.

Retrovirology - 22 Aug 2016

Cosnefroy Ophélie, Murray Philip J, Bishop Kate N

Abstract excerpt

BACKGROUND: Correct disassembly of the HIV-1 capsid shell, called uncoating, is increasingly recognised as central for multiple steps during retroviral replication. However, the timing, localisation and mechanism of uncoating are poorly understood and progress in this area is hampered by difficulties in measuring the process. Previous work suggested that uncoating occurs soon after entry of the viral core into...

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Identifiers

PMID: 27549239
DOI: 10.1186/s12977-016-0292-7
PMCID: PMC4994286

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