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Nuclear Capsid Uncoating and Reverse Transcription of HIV-1

15 Jun 2022

Abstract excerpt

After cell entry, human immunodeficiency virus type 1 (HIV-1) replication involves reverse transcription of the RNA genome, nuclear import of the subviral complex without nuclear envelope breakdown, and integration of the viral complementary DNA into the host genome. Here, we discuss recent evidence indicating that completion of reverse transcription and viral genome uncoating occur in the nucleus rather than in...

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PMID: 35704745
DOI: 10.1146/annurev-virology-020922-110929

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