Article

Gene prioritization based on systems biology revealed new insight into genetic basis and pathophysiology underlying schizophrenia

2020-06-29

Abstract excerpt

Sequencing-based studies have recognized hundreds of genetic variants that increase the risk of schizophrenia (SCZ), but only a few percents of heritability can be attributed to these loci. It is challenging to discover the full spectrum of schizophrenia genes and reveal the dysregulated functions underlying the disease. Here, we proposed a holistic model for predicting disease genes (HMPDG), a novel machine learn...

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Literature Corpus work: 88d773f3-b833-5e3a-9fbb-9e993ff0656a
DOI: 10.1101/2020.06.26.20140541

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