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Article

Germline variants in acquired aplastic anemia: current knowledge and future perspectives.

Haematologica - 1 Sept 2024

Wang Peicheng, Jiang Wanzhi, Lai Tianyi, Liu Qi, Shen Yingying, Ye Baodong, Wu Dijiong

Abstract excerpt

Aplastic anemia (AA) is a disease characterized by failure of hematopoiesis, bone marrow aplasia, and pancytopenia. It can be inherited or acquired. Although acquired AA is believed to be immune-mediated and random, new evidence suggests an underlying genetic predisposition. Besides confirmed genomic mutations that contribute to inherited AA (such as pathogenic mutations of TERT and TERC), germline variants,...

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Identifiers

PMID: 38988263
DOI: 10.3324/haematol.2023.284312
PMCID: PMC11367197

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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