Article
Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia.
Molecular cancer - 4 Feb 2022
Hortal Alejandro M, Oeste Clara L, Cifuentes Claudia, Alcoceba Miguel, Fernández-Pisonero Isabel, Clavaín Laura, Tercero Rut, Mendoza Pilar, Domínguez Verónica, García-Flores Marta, Pintado Belén, Abia David, García-Macías Carmen, Navarro-Bailón Almudena, Bustelo Xosé R, González Marcos, Alarcón Balbino
Abstract excerpt
BACKGROUND: Chronic lymphocytic leukemia (CLL) is the most frequent, and still incurable, form of leukemia in the Western World. It is widely accepted that cancer results from an evolutionary process shaped by the acquisition of driver mutations which confer selective growth advantage to cells that harbor them. Clear examples are missense mutations in classic RAS genes (KRAS, HRAS and NRAS) that underlie the...
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