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Article

Apoptosis and motor deficits in SPG76 hereditary spastic paraplegia: Calpain 2 inhibition as therapeutic strategy.

Pharmacological research - 1 Mar 2026

Brivio Francesca, Guarato Giulia, Panzeri Elena, Manganelli Fiore, Filosto Massimiliano, Vantaggiato Chiara, Bassi Maria Teresa

Abstract excerpt

SPG76 is a complicated form of hereditary spastic paraplegia (HSP) associated with mutations in the CAPN1 gene. The encoded protein, calpain 1, is a calcium-activated cysteine protease that catalyzes the proteolytic cleavage of a variety of cellular proteins and is involved in a wide range of biological processes. Calpain 1 and calpain 2 isoforms are highly expressed in various tissues and have opposite effects...

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Apoptosis
Calpain
Fibroblasts
Mutation
Proto-Oncogene Proteins c-akt

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spastic Paraplegia, Hereditary

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Identifiers

PMID: 41620148
DOI: 10.1016/j.phrs.2026.108115

Genes

CAPN1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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