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Naringenin Ameliorates Drosophila ReepA Hereditary Spastic Paraplegia-Linked Phenotypes

18 Nov 2019

Abstract excerpt

Defects in the endoplasmic reticulum (ER) membrane shaping and the interactions with other organelles seem to be a crucial mechanism underlying Hereditary Spastic Paraplegia (HSP) neurodegeneration. REEP1, a transmembrane protein belonging to TB2/HVA22 family, is implicated in SPG31, an autosomal dominant form of HSP, and its interaction with Atlastin/SPG3A and Spastin/SPG4, the other two major HSP linked...

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PMID: 31803000
DOI: 10.3389/fnins.2019.01202

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