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Article

Recombinant H77C gpE1/gpE2 heterodimer elicits superior HCV cross-neutralisation than H77C gpE2 alone.

Journal of hepatology - 1 Dec 2024

Kundu Juthika, Le Hoa T, Logan Michael, Hockman Darren, Landi Abdolamir, Crawford Kevin, Wininger Mark, Johnson Janelle, Kundu Joydeb K, Tiffney E Alana, Urbanowicz Richard A, Ball Jonathan K, Bailey Justin R, Bukh Jens, Law Mansun, Foung Steven, Tyrrell D Lorne, Houghton Michael, Law John Lokman

Abstract excerpt

BACKGROUND & AIMS: An optimal HCV vaccine requires the induction of antibodies that neutralise the infectivity of many heterogenous viral isolates. In this study, we have focused on determining the optimal recombinant envelope glycoprotein component to elicit cross-neutralising antibodies against global HCV genotypes. We compared the immunoreactivity and antigenicity of the HCV genotype 1a strain H77C-derived...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38986744
DOI: 10.1016/j.jhep.2024.06.029
PMCID: PMC11830426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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