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Article

A trivalent HCV vaccine elicits broad and synergistic polyclonal antibody response in mice and rhesus monkey.

Gut - 1 Jan 2019

Wang Xuesong, Yan Yu, Gan Tianyu, Yang Xi, Li Dapeng, Zhou Dongming, Sun Qiang, Huang Zhong, Zhong Jin

Abstract excerpt

OBJECTIVE: Despite the development of highly effective direct-acting antivirals, a prophylactic vaccine is needed for eradicating HCV. A major hurdle of HCV vaccine development is to induce immunity against HCV with high genome diversity. We previously demonstrated that a soluble E2 (sE2) expressed from insect cells induces broadly neutralising antibodies (NAbs) and prevents HCV infection. The objective of this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29180585
DOI: 10.1136/gutjnl-2017-314870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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