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Article

Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus.

The Journal of infectious diseases - 15 Oct 2011

Meunier Jean-Christophe, Gottwein Judith M, Houghton Michael, Russell Rodney S, Emerson Suzanne U, Bukh Jens, Purcell Robert H

Abstract excerpt

We detected cross-reactive neutralizing antibodies (NtAb) against hepatitis C virus (HCV) in chimpanzees vaccinated with HCV-1 (genotype 1a) recombinant E1/E2 envelope glycoproteins. Five vaccinated chimpanzees, protected following HCV-1 challenge, were initially studied using the heterologous H77 (genotype 1a) HCVpp assay. All animals had developed NtAb after the second vaccination; 4 animals had reciprocal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21917891
DOI: 10.1093/infdis/jir511
PMCID: PMC3203383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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