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Article

Recombinant Flag-tagged E1E2 glycoproteins from three hepatitis C virus genotypes are biologically functional and elicit cross-reactive neutralizing antibodies in mice.

Virology - 1 Jun 2018

Krapchev Vasil B, Rychłowska Malgorzata, Chmielewska Alicja, Zimmer Karolina, Patel Arvind H, Bieńkowska-Szewczyk Krystyna

Abstract excerpt

Hepatitis C virus (HCV) is a globally disseminated human pathogen for which no vaccine is currently available. HCV is highly diverse genetically and can be classified into 7 genotypes and multiple sub-types. Due to this antigenic variation, the induction of cross-reactive and at the same time neutralizing antibodies is a challenge in vaccine production. Here we report the analysis of immunogenicity of recombinant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29631174
DOI: 10.1016/j.virol.2018.03.026
PMCID: PMC5998380

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