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Article

The core domain of hepatitis C virus glycoprotein E2 generates potent cross-neutralizing antibodies in guinea pigs.

Hepatology (Baltimore, Md.) - 1 Apr 2017

Vietheer Patricia T, Boo Irene, Gu Jun, McCaffrey Kathleen, Edwards Stirling, Owczarek Catherine, Hardy Matthew P, Fabri Louis, Center Rob J, Poumbourios Pantelis, Drummer Heidi E

Abstract excerpt

A vaccine that prevents hepatitis C virus (HCV) infection is urgently needed to support an emerging global elimination program. However, vaccine development has been confounded because of HCV's high degree of antigenic variability and the preferential induction of type-specific immune responses with limited potency against heterologous viral strains and genotypes. We showed previously that deletion of the three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27997681
DOI: 10.1002/hep.28989
PMCID: PMC5408392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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