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Article

Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1.

PloS one - 1 Jan 2015

Arena de Souza Victoria, Scott David J, Nettleship Joanne E, Rahman Nahid, Charlton Michael H, Walsh Martin A, Owens Raymond J

Abstract excerpt

Human Carboxylesterase 1 (hCES1) is the key liver microsomal enzyme responsible for detoxification and metabolism of a variety of clinical drugs. To analyse the role of the single N-linked glycan on the structure and activity of the enzyme, authentically glycosylated and aglycosylated hCES1, generated by mutating asparagine 79 to glutamine, were produced in human embryonic kidney cells. Purified enzymes were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26657071
DOI: 10.1371/journal.pone.0143919
PMCID: PMC4676782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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