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Article

IKZF1 alterations in acute lymphoblastic leukemia: The good, the bad and the ugly.

Blood reviews - 1 Nov 2020

Vairy Stephanie, Tran Thai Hoa

Abstract excerpt

Advances in genomics have deepened our understanding of the biology of acute lymphoblastic leukemia (ALL), defined novel molecular leukemia subtypes, discovered new prognostic biomarkers and paved the way to emerging molecularly targeted therapeutic avenues. Since its discovery, IKZF1 has generated significant interest within the leukemia scientific community.IKZF1 plays a critical role in lymphoid development...

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PMID: 32245541
DOI: 10.1016/j.blre.2020.100677

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