Article
Metabolic phenotyping of atherosclerotic plaques reveals latent associations between free cholesterol and ceramide metabolism in atherogenesis.
Journal of proteome research - 6 Mar 2015
Vorkas Panagiotis A, Shalhoub Joseph, Isaac Giorgis, Want Elizabeth J, Nicholson Jeremy K, Holmes Elaine, Davies Alun H
Abstract excerpt
Current optimum medical treatments have had limited success in the primary prevention of cardiovascular events, underscoring the need for new pharmaceutical targets and enhanced understanding of mechanistic metabolic dysregulation. Here, we use a combination of novel metabolic profiling methodolo...
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