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Insulin receptor orchestrates kidney antibacterial defenses

8 Jul 2024

Abstract excerpt

Urinary tract infection (UTI) commonly afflicts people with diabetes. This augmented infection risk is partly due to deregulated insulin receptor (IR) signaling in the kidney collecting duct. The collecting duct is composed of intercalated cells (ICs) and principal cells (PCs). Evidence suggests that ICs contribute to UTI defenses. Here, we interrogate how IR deletion in ICs impacts antibacterial defenses against...

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PMID: 38976738
DOI: 10.1073/pnas.2400666121

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