Article
IL-12 and IL-27 Promote CD39 Expression on CD8+ T Cells and Differentially Regulate the CD39+CD8+ T Cell Phenotype.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 2023
Gerhardt Lara, Hong Megan M Y, Yousefi Yeganeh, Figueredo Rene, Maleki Vareki Saman
Abstract excerpt
Tumor-specific CD8+ T cells are critical components of antitumor immunity; however, factors that modulate their phenotype and function have not been completely elucidated. Cytokines IL-12 and IL-27 have recognized roles in promoting CD8+ T cells' effector function and mediated antitumor responses. Tumor-specific CD8+ tumor-infiltrating lymphocytes (TILs) can be identified based on surface expression of CD39,...
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