Article
The potential benefits of PGC-1α in treating Alzheimer's disease are dependent on the integrity of the LLKYL L3 motif: Effect of regulating mitochondrial axonal transportation.
Experimental gerontology - 1 Sept 2024
Shi Hou-Zhen, Wang Yi-Jie, Wang Yu-Xin, Xu Long-Fei, Pan Wen, Shi Lei, Wang Jia
Abstract excerpt
Mitochondrial dysfunction is a prominent hallmark of Alzheimer's disease (AD). The transcriptional coactivator PPARγ coactivator 1 (PGC-1a) has been identified as a key regulator of mitochondrial biogenesis and function. However, the precise structure/function relationship between PGC-1a and mitochondrial quality control remains incompletely understood. In this study, we investigated the impact of PGC-1a on AD...
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