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Article

PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2014

Dumont Magali, Stack Cliona, Elipenahli Ceyhan, Jainuddin Shari, Launay Nathalie, Gerges Meri, Starkova Natalia, Starkov Anatoly A, Calingasan Noel Y, Tampellini Davide, Pujol Aurora, Beal M Flint

Abstract excerpt

The peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) interacts with various transcription factors involved in energy metabolism and in the regulation of mitochondrial biogenesis. PGC-1α mRNA levels are reduced in a number of neurodegenerative diseases and contribute to disease pathogenesis, since increased levels ameliorate behavioral defects and neuropathology of Huntington's disease,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24398293
DOI: 10.1096/fj.13-236331
PMCID: PMC3963016

Genes

PGC
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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