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Article

The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease.

Brain : a journal of neurology - 1 Mar 2014

Niemann Axel, Huber Nina, Wagner Konstanze M, Somandin Christian, Horn Michael, Lebrun-Julien Frédéric, Angst Brigitte, Pereira Jorge A, Halfter Hartmut, Welzl Hans, Feltri M Laura, Wrabetz Lawrence, Young Peter, Wessig Carsten, Toyka Klaus V, Suter Ueli

Abstract excerpt

The ganglioside-induced differentiation-associated protein 1 (GDAP1) is a mitochondrial fission factor and mutations in GDAP1 cause Charcot-Marie-Tooth disease. We found that Gdap1 knockout mice (Gdap1(-/-)), mimicking genetic alterations of patients suffering from severe forms of Charcot-Marie-Tooth disease, develop an age-related, hypomyelinating peripheral neuropathy. Ablation of Gdap1 expression in Schwann...

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Identifiers

PMID: 24480485
DOI: 10.1093/brain/awt371
PMCID: PMC3927703

Genes

GDAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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