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Interaction of base excision repair gene polymorphism and estrogen-DNA adducts in breast cancer risk among East Asian women.

Breast cancer research and treatment - 1 Nov 2024

Chen Hsing-Wu, Kuo Wen-Hung, Lu Yen-Shen, Chen I-Chun, Hu Fu-Chang, Wang Ming-Yang, Zahid Muhammad, Rogan Eleanor G, Cheng Ann-Lii, Lin Ching-Hung

Abstract excerpt

PURPOSE: In East Asia, the incidence of breast cancer has been increasing rapidly, particularly among premenopausal women. An elevated ratio of estrogen-DNA adducts was linked to a higher risk of breast cancer. The present study explored the influence of the interaction between base excision repair (BER) gene polymorphisms and estrogen-DNA adducts on breast cancer risk. METHODS: We conducted a case-control study...

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PMID: 38969945
DOI: 10.1007/s10549-024-07418-3

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