Article
Synergistic effects of polymorphisms in DNA repair genes and endogenous estrogen exposure on female breast cancer risk.
Annals of surgical oncology - 1 Mar 2010
Ming-Shiean Hsu, Yu Jyh-Cherng, Wang Hsiao-Wei, Chen Shou-Tung, Hsiung Chia-Ni, Ding Shian-ling, Wu Pei-Ei, Shen Chen-Yang, Cheng Chun-Wen
Abstract excerpt
BACKGROUND: Endogenous estrogen is suggested to initiate cell proliferation and cause oxidative DNA damage during breast tumorigenesis. Cells eliminate DNA damage by means of repair enzymes. Genotypic variants of DNA damage repair genes, participating in base excision repair (BER) and nucleotide excision repair (NER) pathways, may act as modifiers that affect the association between estrogen exposure and breast...
Topics
- Breast Neoplasms
- Case-Control Studies
- DNA Glycosylases
- DNA Repair
- DNA, Neoplasm
- DNA-Binding Proteins
- Drug Synergism
- Endonucleases
- Estrogens
- Female
- Genotype