Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Patient-Derived Cells to Guide Targeted Therapy for Advanced Lung Adenocarcinoma.

Scientific reports - 27 Dec 2019

Kim Seok-Young, Lee Ji Yeon, Kim Dong Hwi, Joo Hyeong -Seok, Yun Mi Ran, Jung Dongmin, Yun Jiyeon, Heo Seong Gu, Ahn Beung -Chul, Park Chae Won, Pyo Kyoung Ho, Chun You Jin, Hong Min Hee, Kim Hye Ryun, Cho Byoung Chul

Abstract excerpt

Adequate preclinical model and model establishment procedure are required to accelerate translational research in lung cancer. We streamlined a protocol for establishing patient-derived cells (PDC) and identified effective targeted therapies and novel resistance mechanisms using PDCs. We generated 23 PDCs from 96 malignant effusions of 77 patients with advanced lung adenocarcinoma. Clinical and experimental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma of Lung
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to Exome Sequencing

Share to Flow Cytometry

Share to Immunoblotting

Share to Lung Neoplasms

Share to Protein Kinase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 31882684
DOI: 10.1038/s41598-019-56356-4
PMCID: PMC6934824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Patient-Derived Cells to Guide Targeted Therapy for Advanced Lung Adenocarcinoma.PMID 31882684Read ↗

<em>Ex Vivo</em> Drug Testing of Patient-Derived Lung Organoids to Predict Treatment Responses for Personalized MedicineSemantic proximity Read ↗

Human Lung Adenocarcinoma-Derived Organoid Models for Drug ScreeningSemantic proximity Read ↗

Patient-derived organoids from malignant pleural effusion to explore for alternative therapies in thoracic tumorsSemantic proximity Read ↗

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screeningSemantic proximity Read ↗

Patient-derived cell-based pharmacogenomic assessment to unveil underlying resistance mechanisms and novel therapeutics for advanced lung cancerSemantic proximity Read ↗

Genomic characteristics and drug screening among organoids derived from non‐small cell lung cancer patientsSemantic proximity Read ↗

Establishment, characterization, and drug screening of low-passage patient individual non-small cell lung cancer in vitro models including the rare pleomorphic subentitySemantic proximity Read ↗

An optimized method to culture human primary lung tumor cell spheroidsSemantic proximity Read ↗

Patient-derived cell-based pharmacogenomic assessment to unveil underlying resistance mechanisms and novel therapeutics for advanced lung cancer.Semantic proximity Read ↗

Organoid Cultures as Preclinical Models of Non-Small Cell Lung Cancer.Semantic proximity Read ↗

Establishment and characterization of BMC-PDC-019: a novel patient-derived cell line of EGFR-mutant pulmonary adenocarcinoma transformed into small-cell lung cancer.Semantic proximity Read ↗

Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived XenograftsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.