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Metabolically Stable Chimeric Nucleic Acid Nanoprobe Artificial Biomarker for Cancer Urine Biopsy

14 May 2025

Abstract excerpt

Urine biopsy based on in vitro probes has emerged as a promising method for disease diagnosis. Here, a nanoprobe (designated as GTP) was developed by functionalizing nanomaterials with a chimeric nucleic acid (comprising peptide nucleic acid (PNA) and DNA) and integrating it with an electrochemical biosensor for cancer diagnosis via urine biopsy. The GTP specifically responded to telomerase (TE) at tumor sites,...

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PMID: 40366251
DOI: 10.1021/acs.nanolett.5c02043

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