Article
Low-intensity noise exposure takes an essential part in the mechanism of late-onset hereditary hearing loss caused by Abcc1 mutation.
Clinical genetics - 1 Oct 2024
Jiang Mengzhu, Zhang Shuai, Liu Jing, Pang Bo, Bai Yijiang, Chen Yongjia, Huang Huping, Ling Jie, Mei Lingyun
Abstract excerpt
With the development of the social economy, we are exposed to increasing noise in our daily lives. Our previous work found an ABCC1(NM_004996.3:c.A1769G, NP_004987.2:p.N590S) variant which cosegregated with the patients in an autosomal dominant non-syndromic hearing loss family. At present, the specific mechanism of deafness caused by ABCC1 mutation is still not clear. Using the knock-in mouse model simulating...
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