Article
Mitochondrial DNA common deletion increases susceptibility to noise-induced hearing loss in a mimetic aging rat model.
Biochemical and biophysical research communications - 24 Oct 2014
Yu Jintao, Wang Yanjun, Liu Peng, Li Qingyu, Sun Yu, Kong Weijia
Abstract excerpt
Noise-induced hearing loss (NIHL) is an important occupational health hazard. However, susceptibility to NIHL remains poorly understood. The present study was designed to investigate whether mitochondrial DNA common deletion (CD) increases the susceptibility of individuals to NIHL. A mimetic aging rat model harboring increased CD in the inner ear was established by chronic d-galactose administration, and the...
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