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Article

RhoB plays a central role in hyperosmolarity-induced cell shrinkage in renal cells.

Journal of cellular physiology - 1 Sept 2024

Centrone Mariangela, Saltarella Ilaria, D'Agostino Mariagrazia, Ranieri Marianna, Venneri Maria, Di Mise Annarita, Simone Laura, Pisani Francesco, Valenti Giovanna, Frassanito Maria A, Tamma Grazia

Abstract excerpt

The small Rho GTP-binding proteins are important cell morphology, function, and apoptosis regulators. Unlike other Rho proteins, RhoB can be subjected to either geranylgeranylation (RhoB-GG) or farnesylation (RhoB-F), making that the only target of the farnesyltransferase inhibitor (FTI). Fluorescence resonance energy transfer experiments revealed that RhoB is activated by hyperosmolarity. By contrast,...

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Identifiers

PMID: 38946197
DOI: 10.1002/jcp.31343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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