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Article

APOE epsilon variants and composite risk of dementia, disability, and death in the health and retirement study.

Journal of the American Geriatrics Society - 1 Oct 2024

Clocchiatti-Tuozzo Santiago, Szejko Natalia, Rivier Cyprien A, Renedo Daniela, Huo Shufan, Sheth Kevin N, Gill Thomas M, Falcone Guido J

Abstract excerpt

BACKGROUND: Clinical trials in older adults are increasingly focused on functional outcomes, and the composite outcome of dementia, disability, and death is gaining pivotal importance. Genetic variation, particularly the APOE epsilon(ε) variants, may modify responses to new treatments. Although APOE ε4 is known to influence these outcomes separately, the magnitude of its effect on this composite outcome remains...

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Identifiers

PMID: 38946154
DOI: 10.1111/jgs.19043
PMCID: PMC11461103

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