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Regulation of blood-brain barrier integrity by Dmp1 -expressing astrocytes through mitochondrial transfer

28 Jun 2024

Abstract excerpt

The blood-brain barrier (BBB) acts as the crucial physical filtration structure in the central nervous system. Here, we investigate the role of a specific subset of astrocytes in the regulation of BBB integrity. We showed that Dmp1- expressing astrocytes transfer mitochondria to endothelial cells via their endfeet for maintaining BBB integrity. Deletion of the Mitofusin 2 ( Mfn2 ) gene in Dmp1 -expressing...

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PMID: 38941455
DOI: 10.1126/sciadv.adk2913

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