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Elevated homocysteine is associated with increased rates of epigenetic aging in a population with mild cognitive impairment

27 Jun 2024

Abstract excerpt

Elevated plasma total homocysteine (tHcy) is associated with the development of Alzheimer's disease and other forms of dementia. In this study, we report the relationship between tHcy and epigenetic age in older adults with mild cognitive impairment from the VITACOG study. Epigenetic age and rate of aging (ROA) were assessed using various epigenetic clocks, including those developed by Horvath and Hannum,...

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PMID: 38937999
DOI: 10.1111/acel.14255

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