Article

The principal component-based clinical aging clock (PCAge) identifies signatures of healthy aging and provides normative targets for clinical intervention

2023-07-16

Abstract excerpt

Clinical healthy aging recommendations are disease-centric and reactive rather than focusing on holistic, organismal aging. In contrast, biological age (BA) estimation informs risk stratification by predicting all-cause mortality, however current BA clocks do not pinpoint aging mechanisms making it difficult to intervene clinically. To generate actionable BA clocks, we developed and validated a principal component...

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Literature Corpus work: 66b909cb-2b9c-5d58-986f-d82efb86bae5
DOI: 10.1101/2023.07.14.23292604

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