Article

The principal component-based clinical aging clock (PCAge) identifies signatures of healthy aging and provides normative targets for clinical intervention

2023-08-16

Abstract excerpt

<title>Abstract</title> <p>Clinical healthy aging recommendations are disease-centric and reactive rather than focusing on holistic, organismal aging. In contrast, biological age (BA) estimation informs risk stratification by predicting all-cause mortality, however current BA clocks do not pinpoint aging mechanisms, making it difficult to intervene clinically. To generate actionable BA clocks, we developed and va...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d116686-8895-53bc-9dbe-64f9ae770493
DOI: 10.21203/rs.3.rs-3205910/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The principal component-based clinical aging clock (PCAge) identifies signatures of healthy aging and provides normative targets for clinical interventionDOI 10.21203/rs.3.rs-3205910/v1Read

The principal component-based clinical aging clock (PCAge) identifies signatures of healthy aging and provides normative targets for clinical interventionSemantic proximity Read

Proteomic aging clock (PAC) predicts age-related outcomes in middle-aged and older adultsSemantic proximity Read

AI-driven biological clocks of cardiac aging: Should we integrate ECG, metabolomic, and epigenetic signatures?Semantic proximity Read

Phenome-wide associations of human aging uncover sex-specific dynamics.Semantic proximity Read

Blood Omics Models for System-Specific Mortality Risk EstimationSemantic proximity Read

Making Biological Ageing Clocks PersonalSemantic proximity Read

A Prospective Cohort Study to Develop Multi-Biomarkers Panel to Define Biological Ageing in Five Different Cohorts from Newborn to Oldest Adult: A Study ProtocolSemantic proximity Read

[Recent advances in organ-system-specific biological age].Semantic proximity Read

Chronological Age Reshapes the Molecular Landscape of Polygenic Risk Across the Human LifespanSemantic proximity Read

Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populationsSemantic proximity Read

Associations of proteomic age with mortality and incident chronic diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC)Semantic proximity Read

An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular agingSemantic proximity Read