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Article

Prenatal efavirenz exposure is independently associated with maternal, but not fetal CYP2B6 genotype.

Pharmacogenetics and genomics - 1 Oct 2024

Eniayewu Oluwasegun, Akinloye Abdulafeez, Shenkoya Babajide, Azuka Uche, Bolaji Oluseye, Adejuyigbe Ebunoluwa, Owen Andrew, Olagunju Adeniyi

Abstract excerpt

OBJECTIVES: Understanding the influence of fetal and maternal genetics on prenatal drug exposure could potentially improve benefit-risk evaluation. In this study, we investigated the impact of two functional polymorphisms in CYP2B6 on prenatal exposure to efavirenz. METHODS: Dried blood spot (DBS) samples were collected from HIV-positive pregnant women ( n = 112) and their newborns ( n = 107) at delivery. They...

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Identifiers

PMID: 38934229
DOI: 10.1097/FPC.0000000000000542
PMCID: PMC7616417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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