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Article

Pharmacogenetics of Efavirenz Exposure in Cervicovaginal Fluid during Pregnancy and Postpartum.

Clinical pharmacology and therapeutics - 1 Oct 2024

Eniayewu Oluwasegun, Azuka Uche, Ogah Jonah, Adejuyigbe Ebunoluwa, Bolaji Oluseye, Olagunju Adeniyi

Abstract excerpt

In this study, we investigated the combined influence of pregnancy and genetic polymorphisms on efavirenz pharmacokinetics in cervicovaginal fluid (CVF) of women receiving antiretroviral therapy. Women receiving efavirenz-containing antiretroviral therapy were recruited from two hospitals in Nigeria during 2017-2020. Sparse CVF and plasma samples were obtained during pregnancy to assess the possible association...

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Nigeria
Alkynes
Benzoxazines
Body Fluids
Cytochrome P-450 CYP2B6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Postpartum Period

Pregnancy Complications, Infectious

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Identifiers

PMID: 38859656
DOI: 10.1002/cpt.3343

Genes

CYP2B6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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