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Article

Breast milk pharmacokinetics of efavirenz and breastfed infants' exposure in genetically defined subgroups of mother-infant pairs: an observational study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Aug 2015

Olagunju Adeniyi, Bolaji Oluseye, Amara Alieu, Waitt Catriona, Else Laura, Adejuyigbe Ebunoluwa, Siccardi Marco, Back David, Khoo Saye, Owen Andrew

Abstract excerpt

BACKGROUND: The antiretroviral drug efavirenz is widely used during breastfeeding. Evaluating its safety requires an understanding of its breast milk pharmacokinetics, level of breastfed infants' exposure, and potential influence of polymorphisms in drug disposition genes. METHODS: For this observational study, we investigated plasma and breast milk pharmacokinetics of efavirenz and breastfed infants' exposure in...

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Identifiers

PMID: 25882300
DOI: 10.1093/cid/civ317
PMCID: PMC6542686

Genes

ABCB1
ABCB5
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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