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Article

Genetic variants in CYP2B6 and CYP2A6 explain interindividual variation in efavirenz plasma concentrations of HIV-infected children with diverse ethnic origin.

PloS one - 1 Jan 2017

Soeria-Atmadja Sandra, Österberg Emma, Gustafsson Lars L, Dahl Marja-Liisa, Eriksen Jaran, Rubin Johanna, Navér Lars

Abstract excerpt

BACKGROUND: Approximately 2.6 million children live with HIV globally, and efavirenz (EFV) is one of the most widely used antiretroviral agents for HIV treatment in children and adults. There are concerns about the appropriateness of current EFV dosing and it has been discussed whether EFV dosing should be adapted according to genotype in children as suggested for adults. AIM: To investigate if pediatric EFV...

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Identifiers

PMID: 28886044
DOI: 10.1371/journal.pone.0181316
PMCID: PMC5590735

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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