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Genome-Wide Characterization of Somatic Mutation Patterns in Cloned Dogs Reveals Implications for Neuronal Function, Tumorigenesis, and Aging.

Genes - 18 Jun 2024

Woo Seung-Wan, Kim Miju, Kang Dayeon, Choe Yong-Ho, Oh Seong-Ju, You Are-Sun, Lee Sung-Lim, Kim Jaemin

Abstract excerpt

Studies on somatic mutations in cloned animals have revealed slight genetic variances between clones and their originals, but have yet to identify the precise effects of these differences within the organism. Somatic mutations contribute to aging and are implicated in tumor development and other age-related diseases. Thus, we compared whole genome sequencing data from an original dog with that of cloned dogs,...

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Identifiers

PMID: 38927737
DOI: 10.3390/genes15060801
PMCID: PMC11202621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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