Article
Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC.
Veterinary and comparative oncology - 1 Sept 2023
Sakthikumar Sharadha, Facista Salvatore, Whitley Derick, Byron Sara A, Ahmed Zeeshan, Warrier Manisha, Zhu Zhanyang, Chon Esther, Banovich Kathryn, Haworth David, Hendricks William P D, Wang Guannan
Abstract excerpt
The accrual of cancer mutation data and related functional and clinical associations have revolutionised human oncology, enabling the advancement of precision medicine and biomarker-guided clinical management. The catalogue of cancer mutations is also growing in canine cancers. However, without direct high-powered functional data in dogs, it remains challenging to interpret and utilise them in research and...
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