Article
Comparative Molecular Life History of Spontaneous Canine and Human Gliomas.
Cancer cell - 10 Feb 2020
Amin Samirkumar B, Anderson Kevin J, Boudreau C Elizabeth, Martinez-Ledesma Emmanuel, Kocakavuk Emre, Johnson Kevin C, Barthel Floris P, Varn Frederick S, Kassab Cynthia, Ling Xiaoyang, Kim Hoon, Barter Mary, Lau Ching C, Ngan Chew Yee, Chapman Margaret, Koehler Jennifer W, Long James P, Miller Andrew D, Miller C Ryan, Porter Brian F, Rissi Daniel R, Mazcko Christina, LeBlanc Amy K, Dickinson Peter J, Packer Rebecca A, Taylor Amanda R, Rossmeisl John H, Woolard Kevin D, Heimberger Amy B, Levine Jonathan M, Verhaak Roel G W
Abstract excerpt
Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared the molecular profiles of canine gliomas with those of human pediatric and adult gliomas to characterize evolutionarily conserved mammalian mutational processes in gliomagenesis. Employing whole-genome, exome, transcriptome, and methylation sequencing of 83 canine gliomas, we...
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