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Mitochondrial Dynamics Is Linked to Longevity and Protects from End-Organ Injury: The Emerging Role of Sirtuin 3

14 Mar 2016

Abstract excerpt

SIGNIFICANCE: Mitochondrial integrity is instrumental in protecting against damage associated with aging and a variety of chronic disease conditions. Mitochondrial silent information regulator 3 (Sirt3) plays pivotal roles in maintaining mitochondrial homeostasis by regulating different aspects of the organelle processes. RECENT ADVANCES: Mitochondria are highly dynamic organelles that constantly fuse and divide...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 26972664
DOI: 10.1089/ars.2016.6682

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