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Telomere-related DNA damage response pathways in cancer therapy: prospective targets

7 Jun 2024

Abstract excerpt

Maintaining the structural integrity of genomic chromosomal DNA is an essential role of cellular life and requires two important biological mechanisms: the DNA damage response (DDR) mechanism and telomere protection mechanism at chromosome ends. Because abnormalities in telomeres and cellular DDR regulation are strongly associated with human aging and cancer, there is a reciprocal regulation of telomeres and...

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PMID: 38910895
DOI: 10.3389/fphar.2024.1379166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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